Longitudinal pattern of regional brain volume change differentiates normal aging from MCI

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Longitudinal pattern of regional brain volume change differentiates normal aging from MCI.

BACKGROUND Neuroimaging measures have potential as surrogate markers of disease through identification of consistent features that occur prior to clinical symptoms. Despite numerous investigations, especially in relation to the transition to clinical impairment, the regional pattern of brain changes in clinically normal older adults has not been established. We predict that the regions that sho...

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ژورنال

عنوان ژورنال: Neurology

سال: 2009

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0b013e3181a82634